By Greg Brozeit | Posted - Dec 3rd, 2016





ASH 2016: Kicking It Off With CAR T-Cells


If it’s the first Saturday of December, it must be the beginning of the annual American Society of Hematology (ASH) meeting.  ASH also has it’s equivalent of pre-season, the Friday Satellite Symposia, the day before its official opening, but in this case, it means something.  Twenty-three sessions of two-to-three hours cover virtually every major topic in hematology—lymphomas and leukemias, sickle-cell, biology and, of course, myeloma—to frame major topics and highlight certain upcoming sessions of the four day ASH meeting.

Dr. Stephen Forman from the City of Hope moderated “The Emergence of CAR-T Cell Therapy for Hematologic Malignancies: Moving from Bench to Bedside.”  The participants in the discussion represented the National Cancer Institute, Memorial Sloan-Kettering, and the Hutch in Seattle.  While clinical trials are showing limited success among some patients with lymphomas and leukemias, myeloma CAR-T Cell research is slowly moving toward a time of more clinical trials.  A major issue to solve before trials can proceed is the presence of some neurotoxicity many patients experience.  Virtually every researcher agreed with Dr. Faith Davies of the University of Arkansas, who spoke at the morning MMRF-sponsored session, that a “cocktail” approach, similar to today’s combining drugs, will likely be repeated if and when CAR-T research goes to the clinic.  This will require multiple CAR-T therapies trained to identify differing targets that cause myeloma.

Greg Brozeit
About the Author

Greg Brozeit - Greg Brozeit has been engaged in myeloma patient advocacy since 1998. He began working with the Myeloma Crowd in 2015. Prior to that, he consulted with Dr. Bart Barlogie at the University of Arkansas after working with the International Myeloma Foundation for 15 years, where he inaugurated the public policy advocacy program, patient support group outreach and IMF Europe, organizing more than 100 physician and patient education programs. He earned his BA in political science from Loyola University in New Orleans and lives in northeast Ohio.


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