By Jennifer Ahlstrom | Posted - Jan 8th, 2020

 

 

 

 

ASH 2019: Minimal Residual Disease as a New Clinical Trial End Point

Minimal Residual Disease (MRD) testing is a way of testing how much disease is left after myeloma therapy. MRD testing is now being used more often in the clinic to gauge how well a treatment worked and researchers are hopeful that MRD testing will help clinical trials move along faster. With more myeloma therapies in the clinic, myeloma patients are living longer. This is great news for patients but it makes clinical trials harder to run. Instead of getting results in a 3 year time period, the results may take 5 or 10 years to accrue. 

If MRD testing can be used as a new clinical trial "end point" then clinical trials can be performed to gain new insights. As MRD testing becomes more popular, the data could show when a myeloma patient may want to stop treatment or continue treatment. 

A leading myeloma researcher Nina Shah, MD of UCSF is running many immunotherapy studies such as CAR T or bi-specific antibody (BiTE) studies at her institution. She is also involved in one study using daratumumab/lenalidomide vs. lenalidomide maintenance that is using MRD testing as one of its clinical trial end points. 

Dr. Shah likens today's MRD testing to "wedding china." It's nice to have but you're not sure what to do with it. Can it predict how a myeloma patient will do after therapy is stopped? Not quite yet. But there are some truths we do know today. Being MRD negative is better than being MRD positive (MRD negative patients typically live longer). But we don't know yet if there will be a relationship with overall survival. Clinical trials will be key to understanding how to use MRD testing in a predictive way.

 

        

 
Jennifer Ahlstrom
About the Author

Jennifer Ahlstrom - Jenny A - Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical trials. Founder of Myeloma Crowd, Myeloma Crowd Radio, HealthTree and the CrowdCare Foundation.

ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
 

Add a Comment

 

MORE MYELOMA CROWD NEWS

Thanks to our site sponsors:

.