This is a multicenter, multicountry, open-label, Phase 1b/2a dose-escalation study to determine the maximum tolerated dose of CC-220 when administered as a single therapy and in combination with dexamethasone. CC-220 is a new immunomodulator being developed by Celgene Corporation. The IMiDs are a backbone class of therapies for multiple myeloma. CD-220, also called iberdomide, affects the Cereblon pathway which is one of the mechanisms of action for the immunomodulator drugs.
There are 3 active sites for this trial: The Mayo Clinic Scottsdale, the Karmanos Cancer Institute and at the Winship Cancer Institute.
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