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    • Life With Multiple Myeloma
    • Myeloma 101
    • Jul 22, 2017

    What is a “Line” of Therapy in Multiple Myeloma?

Many myeloma clinical trials include approval criteria based on the number of “lines” of therapy a patient has already received. For example, daratumumab is now approved for patients who have received one prior line of therapy. Other clinical trials require a patient to have over three lines of therapy or more.

But with myeloma therapy typically given in combinations, what does a “line” include? It was confusing enough for myeloma experts Vincent Rajkumar, MD (Mayo Clinic), Paul Richardson, MD (Dana Farber Cancer Institute) and Jesus San Miguel, MD, PhD (University of Navarra, Spain) to better define the criteria in an article in Blood. 

What is a “single line” of therapy?

One line of therapy consists of any of the following:

  1. One complete cycle of a single drug
  2. A combination of several drugs (for example Revlimid/Velcade/dex)
  3. A planned sequence of therapies (for example 6 cycles of induction therapy with Revlimid/Velcade/dex, a stem cell transplant and lenolidomide maintenance)

Seems like a lot of therapy for one line, right? But it’s still considered one line of therapy.

What is a “new line” of therapy?

A new line of therapy would be considered:

  1. Starting a new combination or myeloma treatment if you have stopped all drugs in the prior line of treatment.
  2. The unplanned addition or substitution of one or more drugs in the existing regimen. For example, if you were on a triple combination and the lenalidomide portion stopped working and you started on pomalidomide instead, this would be considered a new line of therapy. 
  3. An additional stem cell transplant if the second transplant was not part of a tandem transplant plan.
  4. If a regimen is interrupted or discontinued for any reason, and then restarted at a later time point but one or more other regimens were administered in between, or the regimen is modified through the addition of one or more agents, then it should be counted as two lines.

Examples might include:

  • Lenalidomide plus low-dose dexamethasone (RD) as initial therapy, and due to inadequate response, bortezomib is added (RVD): This is counted as 2 lines.

  • Toxicity with lenalidomide plus dex as pre-transplant induction, and therefore treatment is switched to bortezomib, cyclophosphamide, and dexamethasone (VCD): RD is counted as 1 line; VCD (and subsequent planned SCT) is line 2.

  • Post-transplant observation without maintenance, and then, due to paraprotein rise 6 months later, lenalidomide is started, which is not planned maintenance; hence, lenalidomide will be considered as a new line.

What is NOT considered a new line of therapy?

  1. If a regimen is interrupted or discontinued for any reason and the same drug or combination is restarted without any other intervening regimen, then it should be counted as a single line.
  2. Changing the dose of an existing medication is not considered a new line of therapy.

If you have other questions on what may qualify you for specific clinical trials, ask your doctor or nurse about your prior lines of therapy. Staying informed is always a smart way to get the most out of your treatment.

About Author

Jenny A

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical trials. Founder of Myeloma Crowd, Myeloma Crowd Radio and the CrowdCare Foundation.

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