Allo Transplant Tip: Skip the Azithromycin and Use Another Antibiotic
Allo Transplant Tip: Skip the Azithromycin and Use Another Antibiotic image
Allo Transplant Tip: Skip the Azithromycin and Use Another Antibiotic
Posted Oct 10, 2017

Allogeneic donor transplant have to carefully watch out for infections following transplant. A lung condition called bronchiolitis obliterans syndrome (BOS) can complicate allo transplant so an antibiotic called azithromycin was tested to counter this type of infection. Researchers recently found, however, that more patient deaths occurred on azithromycin than without. In a study called Azithromycin Increases Mortality After Hematopoietic Stem Cell Transplantation , 480 blood cancer allo transplant patients patients received either 2 years of azithromycin ((250 mg three times weekly) or placebo.

The study was stopped after 13 months when it was determined that the risk for hematologic malignancy relapse was increased with azithromycin versus placebo (33.5% vs. 22.3%; hazard ratio, 1.7; P=0.002).

Azithromycin recipients also had reduced airflow decline–free survival (the primary outcome; 32.8% vs. 41.3%; P=0.03), more cases of BOS (6% vs. 3%), and reduced 2-year survival (56.6% vs. 70.1%; P=0.02). Discontinuation rates were similarly high (>50%) in both treatment groups.

If you are an allo transplant patient, ask your doctor which antibiotics will be most protective and safe for your recovery.

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

More Life with Myeloma Articles

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Bristol Myers Squibb
Janssen Oncology

Follow Us

facebook instagram twitter youtube

Copyright © 2022 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811