/
/
ASCO 2019: Venetoclax Updates with Mike Thompson, MD, PhD, Advocate Aurora Health
ASCO 2019: Venetoclax Updates with Mike Thompson, MD, PhD, Advocate Aurora Health image
ASCO 2019: Venetoclax Updates with Mike Thompson, MD, PhD, Advocate Aurora Health
Posted Jun 18, 2019

Venetoclax is the first drug that was determined to work for a specific type of genetic feature found in multiple myeloma patients called the 11;14 translocation. This means that part of chromosome 11 has swapped places with parts of chromosome 14 on the myeloma cells. This is the most common translocation found in myeloma patients (20% of patients) and is found to be a standard risk feature. Venetoclax works as a BCL-2 inhibitor and other relapsed or refractory myeloma patients can respond to it as well. 

In a Phase 1/2 study (ECOG-ACRIN EAA172), researchers compared daratumumab/bortezomib/dex with daratumumab/bortezomb/dex/venetoclax. In these early studies, safety and dosing are always the goal. This study went on clinical hold (meaning it could not recruit new patients) because of data that came out in a separate study using venetoclax with bortezomib and dex (the BELLINI trial). 

Combination therapy with daratumumab and bortezomib (DVd) has become a standard of care in relapsed/refractory myeloma and the hypothesis is that adding venetoclax could improve outcomes, especially for the t(11;14) patients.

In the Phase II study, 240 patients will be included with 1/3 of patients having t(11;14) and 2/3 of patients having no t(11;14). Investigators are looking forward to the continuation and results of this study. 

 

 

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

More Myeloma News Articles

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Genentech
Abbvie
Bristol Myers Squibb
Janssen Oncology
GSK

Follow Us

facebook instagram twitter youtube

Copyright © 2022 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811

 https://www.guidestar.org/profile/45-5354811