/
/
CLINICAL TRIAL: Selinexor With Stem Cell Transplant
CLINICAL TRIAL: Selinexor With Stem Cell Transplant image
CLINICAL TRIAL: Selinexor With Stem Cell Transplant
Posted May 26, 2016

Researchers are always looking for ways to make stem cell transplant more effective. Here's a new clinical trial opening soon using a new oral agent. The Moffitt Cancer Center in Tampa, Florida is opening a Phase I/II clinical trial using the drug Selinexor to start in July 2016 for approximately 46 patients. Its purpose is to determine the best dose when used in combination with melphalan as a conditioning regimen for a stem cell transplant. The second phase of the study phase will assess the complete response (CR) conversion rate. This study will be used to actively treat participants’ myeloma. Drugs and treatments used will be: auto stem cell transplant, dexamethasone (dex), melphalan, and Selinexor. Selinexor is a new oral drug and is in a new class of agents called Selective Inhibitor of Nuclear Export (SINE™) compounds. Selinexor works by inhibiting XPO1, a protein found in the nucleus of cancer cells, which activates tumor suppressors by retaining them in the nucleus of cancer cells. This causes cell death while sparing normal cells. Selinexor also reduces the levels of cancer generating proteins like C-MYC (learn about this in the Myeloma Crowd Radio Show with Dr. Jay Bradner) and bcl-2, so it is thought that it could also reduce the future growth of cancer cells. Selinexor has already been tested in clinical trials on over 1200 patients. For this clinical trial, patients achieving partial response or a very good partial response with chemotherapy and fewer than three lines of therapy may be eligible to participate. For more information, visit the SparkCures clinical trial summary here: SparkCures Clinical Trial: Selinexor + Stem Cell Transplant  

The author Lizzy Smith

about the author
Lizzy Smith

Lizzy Smith was diagnosed with myeloma in 2012 at age 44. Within days, she left her job, ended her marriage, moved, and entered treatment. "To the extent I'm able, I want to prove that despite life's biggest challenges, it is possible to survive and come out stronger than ever," she says.

More Life with Myeloma Articles

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Genentech
Abbvie
Bristol Myers Squibb
Janssen Oncology
GSK

Follow Us

facebook instagram twitter youtube

Copyright © 2022 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811

 https://www.guidestar.org/profile/45-5354811