An interesting head-on comparison study was presented at ASCO a few days ago in patients with high risk SMM. The study compared “observation” (somewhat akin to ‘do nothing until things get worse’) to starting to treat patients with lenalidomide (Revlimid) early on. Lenalidomide is a drug that is well known to the average multiple myeloma patient as chances are quite high that it may have been used at different stages of our myeloma treatment.
In Phase III of the trial, 90 patients diagnosed with smoldering myeloma were treated with 25 mg of lenalidomide (daily treatment for 3 weeks, then 1 week off), plus 325 mg of aspirin. Disease progression in these patients was followed and compared against 92 smoldering myeloma patients who were regularly monitored for disease progression. The results were impressive :
The lead investigator of the study, Dr. Lonial, commented:
“One thought behind this trial is if you use an immune-enhancing drug, such as lenalidomide, you may be able to enhance that immune control and delay or even prevent conversion from a smoldering state to a symptomatic state.”
about the author
I am a patient diagnosed in 2014 with primary plasma cell leukemia (pPCL), a rare and aggressive variant of multiple myeloma and have been very fortunate to find successful treatment at the division of Cellular Therapy at the Duke University Cancer Institute. My wife, Vicki, and I have two adult children and two grandsons who are the ‘lights of our lives’. Successful treatment has allowed Vicki and I to do what we love best : traveling the world, albeit it with some extra precautions to keep infections away. My career in the pharmaceutical industry has given me insights that I am currently putting to use as an advocate to lower drug pricing, especially prices for anti-cancer drugs. I am a firm believer that staying mentally active, physically fit, compliant to our treatment regimen and taking an active interest in our disease are keys to successful treatment outcomes.