/
/
New Drug GMI-1271 May Help Velcade Work Again in Relapsed Myeloma
New Drug GMI-1271 May Help Velcade Work Again in Relapsed Myeloma image
New Drug GMI-1271 May Help Velcade Work Again in Relapsed Myeloma
Posted May 12, 2017

Velcade is an effective treatment for multiple myeloma, but some patients' myeloma can become resistant to the drug. A new drug called GMI-1271 by GlycoMimetics may restore Velcade's power and once again provide hope to patients, according to a recent article in Leukemia. GMI-1271 blocks E-selectin, an adhesion molecule found in the bone marrow microenvironment.  E-selectin is more prevalent in relapsed myeloma and the finding may provide answers about how myeloma becomes more aggressive and resistant to treatment. In the study, investigators injected myeloma cells into mice. Mice with higher factors that bind E-selectin developed more aggressive myeloma and died earlier. They administered GMI-1271 alone with no impact on the tumor. When researchers gave both Velcade and GMI-1271 together, the myeloma tumor burden was reduced. Dr. John L. Magnani, vice president and chief scientific officer of GlycoMimetics said:

“The results in this preclinical study demonstrate that targeting E-selectin may provide a novel approach to treatment of patients with multiple myeloma and could potentially restore sensitivity to chemotherapy and, in particular, proteasome inhibitor therapy,”

 

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

More Myeloma News Articles

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Genentech
Abbvie
Bristol Myers Squibb
Janssen Oncology
GSK

Follow Us

facebook instagram twitter youtube

Copyright © 2021 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811