BY JEAN LAMANTIA This content is based on information hosted by the National Cancer Institute (NCI), called Cancer Prevention Through Immunomodulation: Does Diet Play a Role? You can listen to the entire presentation here (click “View this webinar” under the Meeting Materials heading).
Vitamin E is a fat-soluble vitamin. It seems to play a role in immune function but its effect is not consistent. For example, elderly subjects given vitamin E supplementation will show an improvement in immune function and reduced respiratory infections. But not everyone experiences this response.
There are two reasons that could account for this in consistent effect. First, not everyone is deficient in vitamin E. People who will show an improvement in immune function with vitamin E supplementation are those who are low in vitamin E. Second, there is a gene-nutrition relationship with vitamin E.
TNFα (Tumor Necrosis Factor Alpha) can be used as an indicator of inflammation in your body. It is a cell signaling protein (cytokine) and one of its primary roles is to regulate immune cells. TNFα has its own genes. The gene can vary by the allele that it contains – either AA, GG or AG. As it turns out, the A allele (AA or AG types) will have higher TNFα levels or in other words, more inflammation. When people who have either AA or AG alleles on their TNFα receive vitamin E supplement, they benefit from the vitamin E by a greater reduction in inflammation. Another important point that Simin Nikbin Meydani, the scientist who presented the vitamin E data, recommends taking note of is that only the elderly benefited from the vitamin E supplementation. She is also quick to point out that vitamin E deficiency in the general public is rare. However, but vitamin E deficiency is increased in populations with fat malabsorption, which would include people with Crohn’s disease, cystic fibrosis or chronic diarrhea. To complete this circle of thought…those who do have a vitamin E deficiency have impaired immune function.
The National Institute of Health states that “evidence to date is insufficient to support taking vitamin E to prevent cancer. In fact, daily use of large-dose vitamin E supplements (400 IU) may increase the risk of prostate cancer.”
If you suspect you are deficient in vitamin E, consult with your physician. You may consider taking 200 IU per day (the amount shown to have the best immune system response). In addition, everyone should include food sources of vitamin E in your diet every day. You should aim for 20 mg per day. This chart from the National Institute of Health shows you some of the dietary sources of vitamin E. Jean LaMantia is a registered dietician, cancer survivor, and best selling author of The Essential Cancer Treatment Nutrition Guide and Cookbook. She can be found at www.jeanlamantia.com. ---------------------------- Don't miss an article from The Myeloma Crowd! To sign up for our weekly newsletter, email us at email@example.com.
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