Once Weekly Kyprolis Dose Better for Myeloma Patients Than Twice Weekly
Posted: Oct 24, 2017
Once Weekly Kyprolis Dose Better for Myeloma Patients Than Twice Weekly image
A once a week dose of Kyprolis (carfilzomib) showed longer progression free survival compared to a twice weekly dose, according to an announcement by Amgen today. Amgen released clinical trial results of their Phase III ARROW clinical trial comparing Kyprolis (carfilzomib) 70 mg/m2 once weekly with a twice weekly 27 mg/m2 administration. In both arms of the study, dexamethasone was given with the Kyprolis. The weekly administration showed 3.6 months longer progression free survival compared to the bi-weekly administration. The overall safety profile of the once-a-week drug was comparable to the twice-weekly. The study included 478 patients with relapsed and refractory multiple myeloma who received two or three prior lines of therapy, including a proteasome inhibitor and an immunomodulatory agent (IMiD). Patients in the trial treated with the once-weekly KYPROLIS regimen achieved a statistically significant superior progression-free survival (PFS) with a median of 11.2 months compared to 7.6 months for those treated with the twice-weekly KYPROLIS regimen (HR = 0.69, 95 percent CI, 0.54 – 0.88).
"KYPROLIS has been demonstrated to be the most effective proteosome inhibitor available to patients with multiple myeloma," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "We are encouraged by the efficacy and safety profile of KYPROLIS and dexamethasone administered once-weekly in the A.R.R.O.W. study."
Proteasomes play an important role in cell function and growth by breaking down proteins that are damaged or no longer needed. Proteasome inhibitors can block the proteasome for myeloma cells, leading to an excessive build-up of proteins within the cell that can cause cell death.
This is good news for patients who will be able to receive a more effective dose with a more convenient schedule.
The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Legend Biotechnologies
Bristol Myers Squibb
Abbvie
Genentech
GSK
Janssen Oncology

Follow Us

facebook instagram twitter youtube

Copyright © 2022 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation for Multiple Myeloma (formerly know as Myeloma Crowd) is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811

 https://www.guidestar.org/profile/45-5354811