/
/
Your Myeloma Antibody Type May Affect How You Respond to Darzalex
Your Myeloma Antibody Type May Affect How You Respond to Darzalex image
Your Myeloma Antibody Type May Affect How You Respond to Darzalex
Posted Oct 24, 2017

A new study in reports that the specific type of heavy and light chain multiple myeloma may affect how the drug Darzalex (daratumumab) works for different patients. Multiple myeloma occurs when one antibody grows out of control, showing a monoclonal protein (M-protein) for one antibody. Antibodies can be grouped into five main subtypes (IgA, IgD, IgE, IgG, and IgM) based on the sequence and structure. Darzalex is an IgG monoclonal antibody that targets the CD38 protein. Janssen, the drug developer of Darzalex, reviewed two Phase II clinical studies with a total of 228 patients to determine if the type of antibody produced by the myeloma cells affected the impact of Darzalex. Their focus was on the difference between IgG and non-IgG myeloma patients. For IgG myeloma patients, Darzalex clearance (or the rate which it is removed from the body) was 110 percent higher compared to non-IgG myeloma patients, meaning the drug is cleared from the body faster in IgG myeloma patients. In spite of the clearance differences, the overall response rates to Darzalex in all patients were similar. Patients also saw similar levels of side effects. However, for the same level of drug exposure, the drug effect was approximately two times higher in IgG versus non-IgG patients. This information is new to us but was shared in part at the 2015 ASH conference. Further studies on relapse rates for Darzalex patients would be fascinating to see and we look forward to seeing future work on the subject.

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

More Myeloma News Articles

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Genentech
Abbvie
Bristol Myers Squibb
Janssen Oncology
GSK

Follow Us

facebook instagram twitter youtube

Copyright © 2022 HealthTree Foundation. All Rights Reserved.

The HealthTree Foundation / Myeloma Crowd is a qualified 501(c)(3) tax-exempt organization. Tax ID 45-5354811

 https://www.guidestar.org/profile/45-5354811