Dr. Siegel’s research has almost exclusively focused on multiple myeloma and has been published in many leading medical journals, including Nature, New England Journal of Medicine, Blood and Journal of Clinical Oncology. Dr. Siegel served as the lead investigator of the pivotal multi-center, phase IIb study involving 30 cancer centers in North America that led to the U.S. Food and Drug Administration’s fast-track approval of Kyprolis (carfilzomib) for relapsed multiple myeloma patients. Dr. Siegel is one of 11 investigators nationwide who brought the chemotherapeutic agent Velcade to multiple myeloma patients through his clinical trials with the medication. Velcade is an injectable drug that blocks some of the chemical pathways associated with unregulated cancer cell growth. Dr. Siegel’s studies have shown that Velcade slows and halts the progression of multiple myeloma. He has also been involved in clinical trials for chemotherapeutic agents Revlimid and Carfilzomib.