Second Study Shows Kyprolis® Improves Overall Survival for Relapsed/Refractory Myeloma

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Final results from the Phase III ASPIRE study were published by Amgen showing that carfilzomib (Kyprolis®) when used with lenalidomide and dexamethasone reduced the risk of death by 21 percent compared to len/dex doublet alone. Median overall survival for carfilzomib-lenalidomide-dex wss 48.3 months vs. lenalidomide-dex at 40.4 months.

“For multiple myeloma patients, the first relapse is usually the most devastating,” said David S. Siegel, M.D., Ph.D., chief of the Division of Multiple Myeloma at John Theurer Cancer Center in Hackensack, N.J., and investigator on the ASPIRE trial. “These data clearly show that the addition of KYPROLIS – for just 18 cycles – to lenalidomide and dexamethasone at relapse gave patients a significantly improved chance of survival. With these results, this KYPROLIS regimen should be considered a new standard of care.”

Kyprolis is currently approved in the U.S. for the following:

  • In combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy.
  • As a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy.

The recent study results are being submitted to a medical conference (most likely the ASH conference) where the data will be presented in more detail.

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Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical trials. Founder of Myeloma Crowd, Myeloma Crowd Radio and the CrowdCare Foundation.

1 Comment

  1. THEY MAKE CLINICAL TRIALS VERY HARD FOR SOME PEOPLE WITH MYELOMA TO DO AND TO GET TO, TRAVELING 2 TO 3 HOURS TO TAKE A PILL FROM A NURSE WHERE IT COULD BE DONE AT A NEAR BY HOSPITAL. I KNOW ABOUT CONTROL BUT ITS INSANE FOR SICK PEOPLE TO TRAVEL HOURS TO GET THERE TO TRIAL TO WAIT AND SEE DR HOURS TO RETURN, ALSO SOMETIMES THEY OFFER MONEY $5O FOR TOLLS PARKING GAS AND FOOD. THAT IS INSANE $50 COVERS JUST TOLLS TODAY, OR A CAR SERVICE IS $100.00 ONE WAY. THESE ARE MILLION DOLLAR COMPANY, STEP UP AND TREAT SICK PATIENTS BETTER THEN YOU DO WITH MORE CONSIDERATION NO LOOKING FOR SICK MYELOMA PATIENTS T5O MAKE MONEY JUST MAKE IT EASY FOR THEM TO GET TO LOCATIONS AND MORE WOULD TAKE PART. THANK YOU VERY MUCH.

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