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    • ASH
    • Multiple Myeloma News
    • Nov 14, 2019

    The 2019 ASH Guide! Myeloma Specialists Choose The Best Myeloma Abstracts For #ASH19

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Myeloma Crowd has made it a priority to help the ASH participants interested in multiple myeloma to find the best and most relevant myeloma abstracts from the total of over 1000 myeloma abstracts listed. Each year over 30,000 Doctors, Researchers, Patient Advocates, and Patients attend the ASH conference, and to say it is confusing and overwhelming would be an understatement. Myeloma Crowd has asked many well known myeloma specialists to aid with this effort.  In addition, many myeloma specialists have provided their own lists. Myeloma specialist Dr. Mike Thompson put together a summary of all the lists provided last year and has been so kind as to do it again this year.  So far he has summarized the best of the best abstracts from Dr. Vincent Rajkumar (Mayo Clinic Rochester), Dr. Saad Usmani(Levine Cancer Institute), Dr. Michael Thompson (Aurora Health Care), Dr. Brian Durie (CEO IMF), and Dr. Daniel Auclair (Chief Scientific Officer for the MMRF).

The myeloma specialists have chosen 28 abstracts from the more than 1000 listed.  We have summarized them below with the Abstract number, The Oral Session in which it will be presented, The Presenter, The date and time, and the Location of the session.  This should provide participants with information they can use to make sure they see some of the most relavent presentations for myeloma at ASH 2019.  As we obtain additional lists we will update this list and add the myeloma specialists providing data. 

Abstract 49 – First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma
Presenter: Edward Stadtmauer
Session: 801. Gene Therapy and Transfer: Advancing CAR T Cells: New Biology and Therapeutic Applications
Saturday, December 7, 2019: 7:30 AM-9:00 AM
W414AB (Orange County Convention Center)

Abstract 136 – Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma
Presenter: Carlos Fernandez de Larrea
Session: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Modeling Cellular Immunity and Tumor Microenvironment in Multiple Myeloma
Saturday, December 7, 2019: 9:30 AM-11:00 AM
Valencia A (W415A) (Orange County Convention Center)

Abstract 141 – Selinexor, Pomalidomide, and Dexamethasone (SPd) in Patients with Relapsed or Refractory Multiple Myeloma
Result Type: Paper
Presenter: Christine Chen
Session: 653. Myeloma: Therapy, excluding Transplantation: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell Discrasias
Saturday, December 7, 2019: 9:30 AM-11:00 AM
Hall E1 (Orange County Convention Center)

Abstract 142 – T(11;14) and High BCL2 Expression Are Predictive Biomarkers of Response to Venetoclax in Combination with Bortezomib and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Biomarker Analyses from the Phase 3 Bellini Study
Presenter: Simon Harrison
Session: 653. Myeloma: Therapy, excluding Transplantation: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell Discrasias
Saturday, December 7, 2019: 9:30 AM-11:00 AM
Hall E1 (Orange County Convention Center)

Abstract 143 – First Clinical Study of the B-Cell Maturation Antigen (BCMA) 2+1 T Cell Engager (TCE) CC-93269 in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Interim Results of a Phase 1 Multicenter Trial
Presenter: Luciano Costa
Session: 653. Myeloma: Therapy, excluding Transplantation: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell Discrasias
Saturday, December 7, 2019: 9:30 AM-11:00 AM
Hall E1 (Orange County Convention Center)

Abstract 259 – Tandem Autologous-Autologous Vs. Autologous-Allogeneic Transplantation for Newly Diagnosed Multiple Myeloma: Pooled Analysis of 1,338 Patients from Four Trials with Long-Term Follow up
Presenter: Luciano Costa
Session: 732. Clinical Allogeneic Transplantation: Results: Outcomes
Saturday, December 7, 2019: 2:00 PM-3:30 PM
W307 (Orange County Convention Center)

Abstract 383 – Outcomes in Multiple Myeloma Based on Comorbidities and Race
Presenter: Martin Schoen
Program: Oral and Poster Abstracts
Session: 903. Health Services Research—Malignant Conditions (Myeloid Disease): Cancer Care Delivery and Quality of Life in Myeloid Malignancies
Sunday, December 8, 2019: 7:30 AM-9:00 AM
W307 (Orange County Convention Center)

Abstract 423 – Racial and Socioeconomic Disparities in the Utilization of Autologous Stem Cell Transplant for Treatment of Multiple Myeloma in the Era of Novel Agents
Presenter: Victoria Vardell
Session: 905. Outcomes Research—Malignant Conditions (Lymphoid Disease): Mountains Conquered, Challenges Remain: Survivorship and Disparities in the Hematologic Malignancies
Sunday, December 8, 2019: 9:30 AM-11:00 AM
W314 (Orange County Convention Center)

Abstract 506 – Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes
Presenter: Cirino Botta
Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Pathogenesis and Bone Marrow Microenvironment
Sunday, December 8, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 509 – The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)
Presenter: Sara Rodríguez
Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Pathogenesis and Bone Marrow Microenvironment
Sunday, December 8, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 572 – Mutations and Copy Number Gains of the BCL2 Family Members Mediate Resistance to Venetoclax in Multiple Myeloma (MM) Patients
Presenter: Paola Neri
Session: 651. Myeloma Biology and Pathophysiology, excluding Therapy: Myeloma Clonal Heterogeneity: Therapeutic and Prognostic Implications
Monday, December 9, 2019: 7:00 AM-8:30 AM
W224CDGH (Orange County Convention Center)

Abstract 577- Results from CARTITUDE-1: A Phase 1b/2 Study of JNJ-4528, a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)
Presenter: Deepu Madduri
Session: 653. Myeloma: Therapy, excluding Transplantation: Novelty in CAR T in Relapsed/Refractory Multiple Myeloma
Monday, December 9, 2019: 7:00 AM-8:30 AM
Hall D (Orange County Convention Center)

Abstract 579 – Long-Term Follow-up of a Phase 1, First-in-Human Open-Label Study of LCAR-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (BCMA), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Presenter: Bai-Yan Wang
Session: 653. Myeloma: Therapy, excluding Transplantation: Novelty in CAR T in Relapsed/Refractory Multiple Myeloma
Monday, December 9, 2019: 7:00 AM-8:30 AM
Hall D (Orange County Convention Center)

Abstract 582 – Efficacy and Safety of Fully Human Bcma Targeting CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma
Presenter: Chunrui Li
Session: 653. Myeloma: Therapy, excluding Transplantation: Novelty in CAR T in Relapsed/Refractory Multiple Myeloma
Monday, December 9, 2019: 7:00 AM-8:30 AM
Hall D (Orange County Convention Center)

Abstract 604 – Outcomes of Transplant-Eligible Newly Diagnosed Ultra-High Risk Myeloma Patients Treated in the NCRI Myeloma XI Trial Indicate the Need for Early Treatment Stratification and Novel Treatment Approaches
Presenter: Martin Kaiser
Session: 731. Clinical Autologous Transplantation: Results: Multiple Myeloma: Results from Prospective Clinical Trials
Monday, December 9, 2019: 7:00 AM-8:30 AM
Sunburst Room (W340) (Orange County Convention Center)

Abstract 691 –  Depth of Response to Daratumumab (DARA), Lenalidomide, Bortezomib, and Dexamethasone (RVd) Improves over Time in Patients (pts) with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Griffin Study Update
Number: 691
Presenter: Peter Voorhees
Session: 653. Myeloma: Therapy, excluding Transplantation: Therapeutics Questions in Newly Diagnosed Myeloma
Monday, December 9, 2019: 10:30 AM-12:00 PM
Hall E1 (Orange County Convention Center)

Abstract 692 – Evaluation of the Prognostic Value of Positron Emission Tomography-Computed Tomography (PET-CT) at Diagnosis and Follow-up in Transplant-Eligible Newly Diagnosed Multiple Myeloma (TE NDMM) Patients Treated in the Phase 3 Cassiopeia Study: Results of the Cassiopet Companion Study
Presenter: Philippe Moreau
Session: 653. Myeloma: Therapy, excluding Transplantation: Therapeutics Questions in Newly Diagnosed Myeloma
Monday, December 9, 2019: 10:30 AM-12:00 PM
Hall E1 (Orange County Convention Center)

Abstract 693 – Treatment of Primary Plasma Cell Leukemia with Carfilzomib and Lenalidomide-Based Therapy: Results of the First Interim Analysis of the Phase 2 EMN12/HOVON129 Study
Presenter: Niels Van De Donk
Session: 653. Myeloma: Therapy, excluding Transplantation: Therapeutics Questions in Newly Diagnosed Myeloma
Monday, December 9, 2019: 10:30 AM-12:00 PM
Hall E1 (Orange County Convention Center)

Abstract 781 – Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd
Presenter: Maria-Victoria Mateos
Session: 731. Clinical Autologous Transplantation: Results: Autologous Stem Cell Transplantation: Lymphoma and Plasma Cell Disorders
Monday, December 9, 2019: 2:45 PM-4:15 PM
W311ABCD (Orange County Convention Center)

Abstract 859 – Daratumumab Plus Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Overall Survival in Alcyone
Presenter: Maria-Victoria Mateos
Session: 653. Myeloma: Therapy, excluding Transplantation: Improving the Outcomes of Newly Diagnosed Multiple Myeloma
Monday, December 9, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 860 – Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (Dara-KRd) Induction, Autologous Transplantation and Post-Transplant, Response-Adapted, Measurable Residual Disease (MRD)-Based Dara-Krd Consolidation in Patients with Newly Diagnosed Multiple Myeloma (NDMM)
Presenter: Luciano Costa
Session: 653. Myeloma: Therapy, excluding Transplantation: Improving the Outcomes of Newly Diagnosed Multiple Myeloma
Monday, December 9, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 862 – Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy Provides Unprecedented MRD Negativity Rates in Newly Diagnosed Multiple Myeloma: A Clinical and Correlative Phase 2 Study
Presenter: Ola Landgren
Session: 653. Myeloma: Therapy, excluding Transplantation: Improving the Outcomes of Newly Diagnosed Multiple Myeloma
Monday, December 9, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 864 – Phase 2 Trial of Daratumumab, Ixazomib, Lenalidomide and Modified Dose Dexamethasone in Patients with Newly Diagnosed Multiple Myeloma
Presenter: Prashant Kapoor
Session: 653. Myeloma: Therapy, excluding Transplantation: Improving the Outcomes of Newly Diagnosed Multiple Myeloma
Monday, December 9, 2019: 4:30 PM-6:00 PM
Hall E2 (Orange County Convention Center)

Abstract 925 – First Analysis from a Phase 1/2 Study of Venetoclax in Combination with Daratumumab and Dexamethasone, +/- Bortezomib, in Patients with Relapsed/Refractory Multiple Myeloma
Presenter: Nizar Bahlis
Session: 653. Myeloma: Therapy, excluding Transplantation: Novel Therapy for Relapsed Myeloma
Monday, December 9, 2019: 6:15 PM-7:45 PM
Valencia A (W415A) (Orange County Convention Center)

Abstract 926 – Phase I/II Study Evaluating the Safety and Efficacy of Venetoclax in Combination with Dexamethasone As Targeted Therapy for Patients with t(11;14) Relapsed/Refractory Multiple Myeloma
Presenter: Jonathan Kaufman
Session: 653. Myeloma: Therapy, excluding Transplantation: Novel Therapy for Relapsed Myeloma
Monday, December 9, 2019: 6:15 PM-7:45 PM
Valencia A (W415A) (Orange County Convention Center)

Abstract 927 – Updated Results from an Ongoing Phase 1 Clinical Study of bb21217 Anti-Bcma CAR T Cell Therapy
Presenter: Jesus Berdeja
Session: 653. Myeloma: Therapy, excluding Transplantation: Novel Therapy for Relapsed Myeloma
Monday, December 9, 2019: 6:15 PM-7:45 PM
Valencia A (W415A) (Orange County Convention Center)

Abstract 928 – Translational Analysis from CARTITUDE-1, an Ongoing Phase 1b/2 Study of JNJ-4528 BCMA-targeted CAR-T Cell Therapy in Relapsed and/or Refractory Multiple Myeloma (R/R MM), Indicates Preferential Expansion of CD8+ T Cell Central Memory Cell Subset
Presenter: Enrique Zudaire
Session: 653. Myeloma: Therapy, excluding Transplantation: Novel Therapy for Relapsed Myeloma
Monday, December 9, 2019: 6:15 PM-7:45 PM
Valencia A (W415A) (Orange County Convention Center)

Abstract 930 – A Bispecific CAR-T Cell Therapy Targeting Bcma and CD38 for Relapsed/Refractory Multiple Myeloma: Updated Results from a Phase 1 Dose-Climbing Trial
Presenter: Heng Mei
Session: 653. Myeloma: Therapy, excluding Transplantation: Novel Therapy for Relapsed Myeloma
Monday, December 9, 2019: 6:15 PM-7:45 PM
Valencia A (W415A) (Orange County Convention Center)

Dr. Michael Thompson’s summary follows, and indicates how many specialists have chosen each of the abstracts.  Some have the interest of as many as 3 different myeloma specialists.  

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About Author

Gary Petersen

Gary is a myeloma survivor and patient advocate. His work centers around helping patients live longer by helping them to find facilities who are beating the average survival statistics. You can find Gary's site at www.myelomasurvival.com and follow him on Twitter at @grpetersen1

3 Comments

  1. Bonnie Falbo November 16, 2019 at 10:19 am

    Gary – thank you so much for compiling this BEST OF list….it helps us prioritize our readings.

  2. Marty Singer November 16, 2019 at 11:41 am

    I was diagnosed 4 yr’s ago with MM. Since then, I have had 2 auto stem cell transplants with the 2nd one being in Jan of 2017. I suffer from peripheral neuropathy on both feet and cronic back pain. The MM caused a fractured spine which causes the constant pain

  3. NCarrera November 20, 2019 at 9:46 pm

    I might add this one as well — Efficacy and Safety of Fully Human Bcma CAR T Cells in Combination with a Gamma Secretase Inhibitor to Increase Bcma Surface Expression in Patients with Relapsed or Refractory Multiple Myeloma

    https://ash.confex.com/ash/2019/webprogram/Paper129405.html

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